Oligonucleotide synthesis
emp BIOTECH has a deep understanding of oligonucleotide synthesis, with extensive knowledge of how reagents behave in manufacturing environments and their impact on reproducibility, change control, and overall process performance. We draw on decades of application experience to offer a comprehensive range of high quality reagents and accessories for every step of RNA and DNA oligonucleotide synthesis, from phosphoramidite coupling to capping, oxidation, sulfurization, and final clean-up.
Whether you’re operating an automated synthesizer or scaling up for therapeutic production, our reagents deliver consistent quality, reliability, and performance.
SOLVENTS AND REAGENTS
MOISTURE CONTROL REAGENTS
Our moisture traps offer exceptional performance for anhydrous chemistry, maintaining water content at or below 30 ppm for organic solvents and solvent mixtures.
Oligo Purification
Our customer promise
emp BIOTECH has been a pioneering provider of high quality reagents for oligonucleotide synthesis since 2002. Over this time, we have continuously refined our operations to ensure that our equipment and processes remain at the forefront of innovation, enabling us to consistently deliver reliable, high performance products to our customers.
But we’re more than just a supplier. We are a strategic partner, using our extensive knowledge of reagents and oligonucleotide synthesis at the process level to provide our customers with a distinct technical advantage.
emp BIOTECH guarantees:
- Processes and systems certified to ISO 9001:2015, and operations aligned with ISO 13485:2016 and ISO 14001:2026 standards
- Fully documented reagents ranging from small scale R&D (100 ml) to large scale production with multi-tonne manufacturing capabilities (up to 25,000 liters per batch)
- Each batch undergoes multiple release tests, including HPLC, GC, Karl Fischer titration, ICP MS, UV vis spectroscopy, NMR, FT IR spectroscopy, refractometry and/or[SP2.1] potentiometry
- Strict acceptance criteria – water ≤10 ppm by Karl Fischer titration and metals ≤5 ppm by ICP MS
- Long term stability – 24 months at 25 °C, and 3 months at 40 °C
- Short lead times of 2 to 6 weeks, depending on the quantity ordered
- A robust quality management system that is transparent, frequently audited, and continually updated
- Proven continuity of supply – even under disruptive conditions – with multiple validated sources of raw materials across diverse geographical locations
- Unwavering partnership, working tirelessly with our customers from the very first conversation to assess individual needs and deliver on schedule
Supplier integration
emp BIOTECH maintains full responsibility for the quality, consistency, and specification alignment of all products we supply, working with selected partners – such as U-genes Biotechnology – to provide specialized manufacturing capabilities, including monomer development and solid phase support production. All materials are then validated, documented, and distributed according to emp BIOTECH’s quality management system.
Our approach ensures:
- Secure and diversified supply chains
- Traceable and compliant raw materials
- Reliable performance in high throughput and GMP workflows
Our team works closely with customers to provide:
- Custom amidite formulations
- Tailored controlled pore glass loadings or pore sizes
- Custom polystyrene formulations
- Technical guidance for synthesis optimization
Made in Germany. Exported to the world.
We have three manufacturing facilities – located in Berlin-Buch, Berlin-Adlershof
and Bitterfeld-Wolfen – which host state-of-the-art R&D labs and mixing and filling plants, as well as a distribution center in the United States and a network of distributors across the globe. This industry-leading infrastructure ensures we can best serve our growing list of global pharmaceutical clients, biotech companies and CRO partners.
